Dealing with the threatening challenges that characterize our era requires the development of knowledge and skills to navigate the uncertainty and complexity of science as part of everyday life. How can we support school students in transforming the base of knowledge and experiences to become agents of transformative change as current complex societal challenges require? This session addresses this broader question through a study framed within the Horizon2020 SEAS project, aimed at promoting new forms of scientific literacy and skills to empower students to become agents of change. The project conceives school science as involving learning and transformation across three spheres where both individuals and their institutional contexts change as participants gain agency.